醫學研究倫理委員會 | 審核通過計畫 (2021)

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計畫名稱	執行期限	審核/修正通過日期	申請人	聯絡電話及郵件
AS-IRB-BM-21001 人工智慧輔助開發癌症精準免疫治療新策略 Using artificial intelligence to assist in developments of new strategies for cancer precision immunotherapy	2021/08/01-2025/07/31	2021/03/31	陳璿宇 Hsuan-Yu Chenn	02-2787-5621
AS-IRB-BM-21002 探討CELF1 在心臟腔室發育及成人型先天性心臟病之角色 Investigating the role of CELF1 in cardiac chamber maturation and adult congenital heart disease	2021/01/14-2022/12/31	2021/01/14 *2022/11/21	王桂馨 Guey-Shin Wang	02-2652-3051
AS-IRB-BM-21006 暴露於高溫油炸環境的工作者之油煙暴露危害研究、抗發炎補充品介入以及烹飪替代方案之成效探討 Innovative methods to reduce emissions and health impacts of deep-frying	2021/03/10-2024/01/01	2021/03/10 2021/08/03 2022/06/01	潘文涵 Pan, Wen-Harn	02-27899121
AS-IRB-BM-21007 口內電訊號語音處理 Voice conversion of telecom signals in the mouth	2021/04/08-2023/12/31	2021/04/08	曹昱 Yu Tsao	02-2787-2300
AS-IRB-BM-21008 基於機器學習及訊號處理之溝通輔具演算法開發及系統實踐 Machine-learning and Signal Processing to Assistive Oral Communications Devices	2021/05/06-2023/12/31	2021/05/19 2022/01/28 2022/12/21	曹昱 Yu Tsao	02-2787-2300
AS-IRB-BM-21009 結合統計科學與人工智慧之數據分析法來探討臺灣重要疾病之健康促進與精準醫療 Integrative data analytics of statistical science and artificial intelligence for health promotion and precision medicine of important diseases in Taiwan	2021/03/04-2025/12/31	2021/03/04	楊欣洲 Hsin-Chou Yang	02-27875686
AS-IRB-BM-21011 開發以嗜中性球及嗜中性球蛋白酶為基礎的氣喘精準化醫療 Translating neutrophils and neutrophil elastase to achieve precision medicine in asthma	2021/08/01-2026/12/31	2021/04/08	李永凌 Yungling Lee	02-2652-3013
AS-IRB-BM-21012 重建人類海馬迴突觸分子之三維空間分布 Reconstructing the three dimension array of synaptic molecules in human hippocampus	2021/09/01-2027/08/31	2021/05/31	程淮榮 Hwai-Jong Cheng	02-2789-9971
AS-IRB-BM-21013 以病例世代研究探討宿主與病毒感染史交互作用對於消化系統癌症發生風險 A case-cohort study to investigate interactions of host and virus infection history on the risk for gastrointestinal cancers	2021/06/23-2026/04/01	2021/06/23	楊懷壹 Hwai-I Yang	02-27871308
AS-IRB-BM-21014 鑑定並箝制肝細胞癌之阿基里斯之踵 Identifying and targeting the Achilles' heel of hepatocellular carcinoma	2021/08/01-2024/07/31	2021/05/31	施修明 Hsiu-Ming Shih	02-2562-3520
AS-IRB-BM-21017 語意變異與訊息累積在詞彙語意表徵建立中所扮演的角色 The roles of semantic diversity and information accumulation in the formation of semantic representation	2021/08/01-2024/07/31	2021/05/17	李佳穎 Chia-Ying Lee	02-26525031
AS-IRB-BM-21018 N-α-乙醯轉移酶10蛋白於胚胎大腦發育與成年海馬迴調控神經突觸延展之功能與機制探討 Understanding Naa10p-mediatd neurite outgrowth in embryonic neurogenesis and adult hippocampal function	2021/08/01-2024/07/31	2021/05/31	阮麗蓉 Li-Jung Juan	02-27871234
AS-IRB-BM-21019 宿主、微生物菌相與肝臟疾病之關聯性研究 Associations of host, microbiota and liver diseases	2021/06/04-2024/12/31	2021/06/04	楊懷壹 Hwai-I Yang	02-27871308
AS-IRB-BM-21020 HIV-1感染過程中galectin-3對細胞內囊泡和細胞的調節作用 The role of galectin-3 in regulation of intracellular vesicle and cells during HIV-1 infection	2021/08/01-2025/07/31	2021/06/22	陳煥源 Huan-Yuan Chen	02-26523940
AS-IRB-BM-21022 建立在non-coding區域上基因體與轉譯體上變異之間的階層性關連 Building hierarchical associations between genomic/epigenomic alterations on non-coding regions and transcriptomic variations of genes	2021/06/01-2024/05/31	2021/06/01	楊振翔 Chen-Hsiang Yeang	02-27875671
AS-IRB-BM-21023 人們如何評斷社會支配關係中的位階高低？一個結合計量法、問卷實驗、以及腦造影實驗的整合研究 How is status ranked in social dominance? An integrated study of socio-metrics, vignette experiment and neuroimaging experiment	2021/08/01-2024/07/31	2021/06/18 2022/08/30 暫停執行 2022/12/21 同意繼續執行	江彥生 Yen Sheng Chiang	02-26525111
AS-IRB-BM-21024 運用深度學習及健康與基因體大數據評估高齡族群健康與疾病風險 Improving Elder Health Care and Assessing Risks of Ageing Diseases by Exploring and Exploiting Health and Genomic Data by Deep Learning	2021/08/01-2025/07/31	2021/07/05	林仲彥 Chung-Yen Lin	02-27883799
AS-IRB-BM-21026 基於機器學習理論噪音消除技術結合臉部影像處理和眼動追蹤技術之多模態語音增強 Multimodal Speech enhancement using machine learning-based noise reduction and facial image processing techniques	2021/08/18-2024/06/30	2021/08/18	曹昱 Yu Tsao	02-2787-2300
AS-IRB-BM-21029 建構台灣族群之染色體外環狀 DNA 輿圖及其相關之疾病風險 Extrachromosomal circular DNA landscape of Taiwanese population and its associated disease risks	2021/08/1-2024/07/31	2021/07/13 2021/08/31 2023/09/11	蔡懷寬 Huai-Kuang Tsai	02-27883799 #1718
AS-IRB-BM-21030 以多數據彙整分析研究大腸直腸癌之新穎檢驗與治療策略 Multi-data analysis of colorectal cancer research	2021/07/30-2026/12/31	2021/07/15	孟子青 Tzu-Ching Meng	02-27855696 #6010
AS-IRB-BM-21032 以多層次整合途徑探討兒童肥胖的成因: 個人、家庭與地理環境 A multilevel integrated approach for elucidating the etiology of pediatric obesity: individual, family and environment	2021/09/01-2026/12/31	2021/07/30 *2021/11/15	詹大千 Ta-Chien Chan	02-2785-7108 #312
AS-IRB-BM-21034 透過脂肪庫特異性表觀遺傳調控機制以預測肥胖時腹部脂肪堆積和胰島素抗性（整合型計畫）：利用全基因體表觀遺傳基因體關聯性分析建立預測人類肥胖的精準醫學模式（子計畫二） Identifying fat-depot specific epigenomics regulation for predicting obesity-associated central fat accumulation and insulin resistance: Predicting human obesity by composite epigenome-wide association study (EWAS) towards precision medicine	2022/01/01-2025/12/31	2021/07/30 *2022/07/18	陳柏仰 Pao-Yang Chen	02-27871140
AS-IRB-BM-21035 廣泛分析影響低惡性度膠質瘤惡性轉化之環狀RNA、多樣性剪接與RNA編輯 Global analysis of circular RNA、RNA splicing and RNA editing associated with malignant transformation in low-grade glioma	2021/11/26-2027/10/01	2021/11/26 *2022/08/29	莊樹諄 Trees-Juen Chuang	02-27871244
AS-IRB-BM-21036 全表型全基因體關聯性研究之疾病基因定位與風險預測以及糖尿病之孟德爾隨機化研究 Phenome-wide genome-wide association studies for disease gene mapping and risk prediction, and Mendelian randomization for diabetes	2022/01/01-2024/12/31	2021/08/12 *2023/02/13	陳君厚 Chun-Houh Chen	02-27875660
AS-IRB-BM-21038 建立剖析 SARS-CoV-2 感染程序的 NGS 分析模型 Establishing NGS analytical model for understanding the infectious program of SARS-CoV-2	2022/01/01-2027/12/31	2021/11/01	楊欣洲 Hsin-Chou Yang	02-27875686
AS-IRB-BM-21039 第三型半乳糖凝集素在皮膚缺血性壞死過程之功能 Roles of galectin-3 in skin ischemic necrosis	2022/10/20-2024/12/31	2021/10/20	陳煥源 Huan-Yuan Chen	02-26523940
AS-IRB-BM-21040 利用台灣人體生物資料庫進行肝癌個人化預測模式之驗證研究 Validation of Risk Prediction Models for Hepatocellular Carcinoma using Taiwan Biobank	2022/01/01-2026/12/31	2021/09/03	楊懷壹 Hwai-I Yang	02-27871308
AS-IRB-BM-21041 以肌醇單磷酸酶和分泌胞外體作為肺癌治療的標的-動物模型建立以及臨床病理評估 Using inositol monophosphatase to secrete exosomes as the targetestablishment of in vivo model and clinical pathological evaluation for the treatment of lung cancer	2022/07/01-2024/12/31	2021/12/07	蕭宏昇 Michael Hsiao	02-27871243
AS-IRB-BM-21042 右心室出口處心律不整的基因體研究（總計畫）: 右心室出口處心律不整的泛基因體掃描遺傳相關研究（子計畫一）右心室出口處心律不整的泛基因體研究及定序整合分析（子計畫二） Genomewide association study for right ventricular outflow trace arrhythmia : Genomewide Association Study for Right Ventricular Outflow Tract Ventricular Arrhythmia (project1); Integrative analysis of whole exome sequence and genome wide association for right ventricular outflow trace arrhythmia (project2)	2022/01/01-2022/12/31	2021/08/25 2022/12/20 2023/09/11	范盛娟 Cathy SJ Fann	02-27899144
AS-IRB-BM-21043 總計畫：非酒精性脂肪肝疾病及肝硬化之細胞因子及基因體研究子計畫一：CLEC18在非酒精性脂肪肝疾病之致病角色子計畫二：細胞因子在非酒精性脂肪肝疾病之致病角色 Main Project：The cellular factors and genomics in non-alcoholic fatty liver disease and liver cirrhosis Subproject 1：The pathogenic role of CLEC18 in non-alcoholic fatty liver disease Subproject 2：The pathogenic role of cellular factors in nonalcoholic fatty liver disease	2022/01/01-2024/12/31	2021/09/29 *202212/01	謝世良 Shie-Liang Hsieh	02-27871245
AS-IRB-BM-21044 病人候診語音互動系統之建置及可行性與效益評估 The feasibility and benefit assessment of automatic speech recognition outpatient waiting room and clinic visit	2022/01/01-2024/12/31	2021/12/07	曹昱 Yu Tsao	02-27872300
AS-IRB-BM-21047 以口香糖咀嚼、影像辨識與個人健康資訊整合改善高齡者咀嚼功能與營養 Improving elderly masticatory function and nutrition by chewing gum, image recognition, and personal health informatics	2022/10/20-2026/06/30	2021/10/20 2021/11/12 2022/01/28 *2022/08/30	詹大千 Ta-Chien Chan	02-27857108 #312
AS-IRB-BM-21048 具血緣關係的家庭成員臉型合成 Kinship Face Synthesizer	2021/11/12-2022/12/31	2021/11/12	陳駿丞 Jun-Cheng Chen	02-27872356
AS-IRB-BM-21050 電子喉語音轉換 Electrolarygeal voice conversion	2021/12/14-2022/11/15	2021/12/14 *2023/02/07	王新民 Hsin-Min Wang	02-27883799 #1714
AS-IRB-BM-21051 發展anti-CD33 (Siglec-3)抗體以治療慢性B 型肝炎 Development of anti- CD33 (Siglec-3) mAb for the treatment of chronic hepatitis B infection	2021/11/12-2023/12/31	2021/11/12	謝世良 Shie-Liang Hsieh	02-27871245
AS-IRB-BM-21052 第二語閱讀理解歷程中主動詞一致性判斷之神經機制 Underlying mechanism of subject-verb agreement in sentence comprehension for second language acquisition	2021/11/01-2026/09/30	2021/11/01 *2022/06/30	李佳穎 Chia-Ying Lee	02-26525031
AS-IRB-BM-21055 嗜中性白血球胞外網狀結構在PM2.5所引發的呼吸道過度反應與發炎之機轉探討 Investigating the role of neutrophil extracellular traps in fine particulate matter (PM2.5)-induced airway hyperreactivity and inflammation	2022/08/01-2025/07/31	2021/12/13 *2023/09/11	張雅貞 Ya-Jen Chang	02-27899050
AS-IRB-BM-21056 晝夜節律紊亂和核心時鐘基因BMAL1與BMAL2對卵巢上皮細胞癌之影響 Deciphering the effects of circadian disruption and the functions of co	2022/02/14-2026/12/31	2022/02/14 *2023/03/08	黃雯華 Wendy Hwang-Verslues	02-27871246
AS-IRB-BM-21057 探討腎臟移植病患對於新冠病毒疫苗反應之影響因子 To explore factors affecting the response of kidney transplant recipients to the SARS-CoV-2 vaccine	2022/01/01-2024/12/31	2021/12/27	柯泰名 Tai-Ming Ko	02-26523591
AS-IRB-BM-21060 探討中心粒蛋白STIL在表皮生長因子受體EGFR所誘發肺癌形成所扮演的角色 Deciphering the role of STIL in EGFR-driven lung cancer development	2022/08/01-2025/07/31	2021/12/27 *2023/09/11	唐堂 Tang K. Tang	02-26523901
AS-IRB-BM-21061 藉由促進粒線體自噬反應達成抑制tau蛋白誘發粒線體功能缺陷並阻斷阿茲海默症腦部神經突觸功能異常 To Determine Whether Pharmacological Augmentation of Mitophagy Can Prevent Tau-elicited Mitochondrial Deficits to Block Synaptic Dysfunctions in AD.	2022/01/17-2023/12/31	2022/01/17	廖永豐 Yung-Feng Liao	02-27870514
AS-IRB-BM-21063 Follistatin-like 1 在肺腺癌化療敏感性中的分子機制研究 Molecular mechanistic investigations of Follistatin-like 1 in lung adenocarcinoma chemosensitivity	2022/08/01-2025/07/31	2022/01/27	蕭宏昇 Michael Hsiao	02-27871243
AS-IRB-BM-21064 遺傳性視網膜退化疾病的基因體研究與功能分析 Genomic and Functional analysis for hereditary retinal dystrophies	2022/01/17-2023/09/30	2022/01/17 *2023/09/25	鄔哲源 Jer-Yuarn Wu	02-27899075
AS-IRB-BM-21066 惡性腫瘤之唾液酸化醣蕚與髓系免疫細胞之交互作用對顱內神經免疫的影響 The impact of sialylated glycocalyx of malignant tumors on intracranial neuroimmunity through interaction of myeloid cells	2022/08/01-2026/07/31	2022/03/28	陳繪名 Hui-Ming Chen	02-27872067

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計畫名稱	執行期限	審核/修正通過日期	申請人	聯絡電話及郵件
AS-IRB-BM-21003 探討流感疫苗預防注射與侵襲性麴菌病之關聯性 Elucidating the association between the influenza vaccination and the incidence of invasive aspergillosis	2021/02/01-2024/12/31	2021/01/19	詹大千 Ta-Chien Chan	02-2785-7108 #312
AS-IRB-BM-21005 透過社會科學與運算科學的混合取徑了解人類與機器的假新聞判別 A Hybrid Approach to Fake News Authentication and Detection	2021/03/30-2021/12/31	2021/03/30 2022/01/13 結案	賴至慧 Chih-Hui Lai	02-27898130
AS-IRB-BM-21010 人類全胚胎三維細胞結構之發育圖譜研究 The study of neuronal development in human embryonic whole-brain three dimensional cytoarchitecture mapping	2021/04/08-2023/12/31	2021/04/08 2021/11/12 2022/01/28	陳壁彰 Bi-Chang Chen	02-2787-3133
AS-IRB-BM-21015 利用乳癌患者來源的腫瘤球體評估腫瘤治療反應與監控 Establishment of patient-derived tumor spheroids from breast cancer for assessment of clinical responses and monitoring	2021/05/31-2031/04/29	2021/05/31 *2021/09/17	張瑛芝 Ying-Chih Chang	02-27871277
AS-IRB-BM-21016 研究肺癌患者中循環腫瘤細胞之腫瘤異質性 Molecular characterization of tumor heterogeneity in circulating tumor cells (CTCs) among patients with lung cancer	2021/05/31-2024/02/28	2021/05/31	張瑛芝 Ying-Chih Chang	02-27871277
AS-IRB-BM-21027 以人腦活動重建聲音信息 Reconstructing perceived sounds from human brain activity	2021/08/11-2023/07/31	2021/08/11 2021/10/20 2021/11/05	蘇黎 Li Su	02-27883799
AS-IRB-BM-21028 以晚期非小細胞肺癌循環癌細胞建立患者來源腫瘤類器官以預測病患的化學治療反應 Establishment of patient-derived tumor organoids from circulating tumor cells for chemotherapy response prediction in advanced non-small-cell lung cancer	2021/08/18-2026/07/31	2021/08/18 *2023/02/07 (撤案) 2023/03/22 結案	張瑛芝 Ying-Chih Chang	02-27871277
AS-IRB-BM-21031 人工智慧輔助口語溝通裝置 AI based Assistive Oral Communication Devices	2021/09/18-2023/07/31	2021/09/18	曹昱 Yu Tsao	02-2787-2300
AS-IRB-BM-21033 慢性B型肝炎肝功能正常或輕微異常者的肝癌風險分層：一個以社區為基礎的世代研究 Risk stratification for hepatocellular carcinoma in chronic HBV infection with normal or minimally raised ALT: a community-based cohort study	2022/01/01-2022/12/31	2021/8/18	陳建仁 Chien-jen Chen	02-27871302
AS-IRB-BM-21046 探討腫瘤微環境中DNA損害反應與T細胞磨耗的關係 Investigating the link between DNA Damage Response and T cell Exhaustion within tumor microenvironment	2022/01/01-2022/12/31	2021/10/25	陳世淯 Shih-Yu Chen	02-26523994
AS-IRB-BM-21049 長鏈非轉譯核醣核酸—LINAT在腫瘤惡性化中扮演的角色 The roles of long noncoding RNA LINAT in tumor progression 子計畫1：一個新穎長非轉譯核醣核酸LINAT 於乳癌進程之調控機轉與功能分析子計畫2：一個新穎長非轉譯核醣核酸LINAT 於肝癌進程之調控機轉與功能分析	2021/10/15-2023/07/31	2021/10/15	陳瑞華 Ruey-Hwa Chen	02-27855696 #6020
AS-IRB-BM-21059 腫瘤抑制蛋白BTG3於核苷酸切除修復以及皮膚癌的角色探討 To investigate the role of tumor suppressor BTG3 in nucleotide excision repair and skin cancer	2022/08/01-2025/07/31 *2023/09/21結案	2021/12/27	謝小燕 Sheau-Yann Shieh	02-26523916
AS-IRB-BM-21065 精準醫學的展望：運用基因數據驅動集群分析方法識別與驗證複雜性疾病之內在生物表現型 Towards Precision Medicine: Endophenotypes Identification and Validation Utilizing Genomic Data-Driven Clustering Approaches in Complex Diseases (ENDEaVour Study)	2022/08/01-2024/07/31	2022/01/04	范盛娟 Cathy SJ Fann	02-27899144

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自99年10月1日起，本院醫學研究倫理委員會審核通過之計畫於執行期間，進行無實質造成受試者風險及利益改變之微小修正，經本院醫學研究倫理委員會審核同意可不需另行通知受試者之資訊公告如下，歡迎查閱。

計畫名稱

執行期限

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申請人

聯絡電話及郵件

AS-IRB-BM-21034
透過脂肪庫特異性表觀遺傳調控機制以預測肥胖時腹部脂肪堆積和胰島素抗性（整合型計畫）：利用全基因體表觀遺傳基因體關聯性分析建立預測人類肥胖的精準醫學模式（子計畫二）
Identifying fat-depot specific epigenomics regulation for predicting obesity-associated central fat accumulation and insulin resistance: Predicting human obesity by composite
epigenome-wide association study (EWAS) towards precision medicine

2022/01/01-2025/12/31

2021/07/30

*2022/07/18
(展延)

陳柏仰
Pao-Yang Chen

02-27871140

執行中之計畫
已結案計畫
微小修正資訊
撤案

計畫名稱	執行期限	審核/修正通過日期	申請人	聯絡電話及郵件
AS-IRB-BM-21021 人類肺癌微生物菌群與代謝物探討 The microbiome and metabolome of human lung tumour	2021/06/22-2026/12/31	2021/06/22 2021/12/27 撤案	謝清河 Patrick Ching-Ho Hsieh	02-27899170
AS-IRB-BM-21045 女性乳癌風險預測模式驗證與改善以及高風險者飲食運動介入預防成效評估計畫(總計畫) 台灣婦女乳癌風險Gail Model預測模式應用及精準篩檢策略之研究(分項計畫一)；乳癌之基因風險評估與早期診斷(分項計畫二)；生活型態（飲食、體能活動）與乳癌發生風險之探討(分項計畫三)；飲食運動介入對高風險婦女乳房病變發生之影響(分項計畫四)；雌激素相關標記預測停經前婦女乳癌風險及飲食運動介入的成效(分項計畫五) Validation and improvement of breast cancer prediction model andefficacy of diet and exercise intervention for high risk females(Whole project); Application of Taiwan Gail Model to Predict Risk of BreastCancer and Research for Precision Screening Strategies (Program1)； Establishing genetic score for breast cancer risk assessment andearly detection (Program 2)； Modifiable lifestyles (diet and physical activity) associatedwith breast cancer risk minimization (Program 3)； Effect of dietary and physical activity intervention on breast cancer risk (Program 4)； Biomarkers to predict breast cancer risk and efficacy of dietary and exercise intervention: focus on estrogen and lipid metabolites (Program 5)	2022/01/01-2028/12/31	2021/11/12 2021/12/24 撤案	潘文涵 Pan, Wen-Harn	02-27899121