醫學研究倫理委員會 | 審核通過計畫 (2017)

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計畫名稱	執行期限	審核/修正通過日期	申請人	聯絡電話及郵件
AS-IRB-BM-17003 探索序列資料的維度降低與連鎖分析在稀少性變異資料的應用議題 Exploring the issues of dimension reduction and the usage of rare variants in linkage analysis with sequence data	2017/03/08-2023/12/31	2017/03/08 2020/03/30 2022/03/16	范盛娟 Cathy Shen-Jang Fann	02-27899144
AS-IRB-BM-17005 Linking spirituality and religiosity to life and health expectancy: A global comparative study	2017/02/03-2020/07/31	2017/02/03 2017/02/20 2017/03/10	邱紀尊 Chi-Tsun Chiu	02-37897224
AS-IRB-BM-17006 結合dbGap 和 Taiwan Biobank 資料庫以偵測族群異質性分析及基因交互作用 Investigating gene-gene interaction and population heterogeneity by combining dbGap and Tiawan Biobank databases	2017/03/08-2025/12/31	2017/03/08 2017/10/12 2018/01/22 2018/05/08 2019/07/22 2019/10/03 2020/03/18 2020/04/28 2022/07/08 *2023/12/12	范盛娟 Cathy Shen-Jang Fann	02-27899144
AS-IRB-BM-17008 以藥物高效率由人類皮膚纖維母細胞產生誘導式神經系統細胞 Efficiently reprogramming of human skin fibroblasts into neural system lineage cells by chemicals	2017/04/10-2023/12/31	2017/04/10 2018/02/05 2019/04/12	呂仁 Jean Lu	02-27899580 #601
AS-IRB-BM-17015 探討長鏈非編碼RNA NORAD 在乳癌及肺癌轉移之調控與功能 Unravelling the regulation and function of LncRNA NORAD in breast and lung cancer	2018/01/01-2021/12/31	2017/03/15 *2018/07/20	陳瑞華 Ruey-Hwa Chen	02-27855696 #6020
AS-IRB-BM-17018 整合性多元高解析度資訊之台灣熱浪脆弱度評估 Integrated Multi-source and High-resolution Heat Wave Vulnerability Assessment of Taiwan	2017/08/07-2024/12/31	2017/08/07 2018/01/12 2021/12/14	龍世俊 Shih-Chun Candice Lung	02-26539885 #277
AS-IRB-BM-17024 分析流行性感冒疫苗所引發人類免疫反應之特性 Characterizing human immune response to influenza vaccine	2017/07/12-2022/06/30	2017/07/12 *2018/02/27	楊安綏 An-Suei Yang	02-27871232
AS-IRB-BM-17032 研究肝炎病毒感染及異常脂肪生成途徑以發掘治療肝癌之新穎標的與策略 Targets Identification and Therapeutic Development on Hepatitis Virus Infection and Aberrant Lipogenesis in Hepatocellular Carcinoma	2017/08/07-2020/07/31	2017/08/07	周玉山 Yuh-Shan Jou	02-26523521
AS-IRB-BM-17033 解析轉移癌巨噬細胞之分子機制並制定治療策略 Deciphering the mechanism of macrophages in metastatic tumors and development of therapeutic strategies	2017/08/07-2020/12/31	2017/08/07	陳柏仰 Pao-Yang Chen	02-27871140
AS-IRB-BM-17034 鑑定肌萎縮性脊髓側索硬化症病人組織中TDP-43 蛋白堆積物的形態 Identify the morphology of TDP-43 protein inclusions in the tissue of ALS	2017/09/01-2028/09/01	2017/06/27 2021/09/13 2023/09/07	陳韻如 Yun-Ru Chen	02-27871275
AS-IRB-BM-17036 尋找與大腸直腸癌易感性與癌症演進相關的基因與致癌性miRNA研究合作計劃（3） Identification of Genes and Oncogenic miRNAs Involved in Colorectal Cancer Susceptibility and Progression (3)	2017/08/09-2025/12/31	2017/08/09 2018/07/26 2022/11/21	李玲慧 Ling‐Hui Li	02-27899078
AS-IRB-BM-17040 居住安排與健康餘命之關係 The association between living arrangement and health expectancy	2017/08/30-2020/08/31	2017/08/30 *2018/07/30	邱紀尊 Chi-Tsun Chiu	02-37897224
AS-IRB-BM-17042 建立整合式登革熱監測網 Implementing integrated surveillance network of dengue fever	2017/10/13-2025/07/31	2017/10/13 2020/09/21 2022/06/06	詹大千 Ta-Chien Chan	02-27857108 #312
AS-IRB-BM-17049 開發大型人體生物資料庫與健康資料庫之統計分析方法與工具 – 以台灣人體生物資料庫和台灣全民健保資料庫資料為基礎 Developing statistical methods and analysis platform for the biobank and electronic health record studies – using the data in the Taiwan Biobank and National Health Insurance Research Database	2018/02/27-2022/12/31	2018/02/27 2018/06/07 2019/04/24 2019/07/30 2019/12/30 2020/03/13 2020/09/10 2020/12/22 2023/02/07 *2024/01/23	楊欣洲 Hsin-Chou Yang	02-27835611 #113
AS-IRB-BM-17053 臺灣人類基因組研究計畫 Taiwan Human Genome Project	2018/01/30-2027/12/31	2018/01/30 2019/06/18 2022/02/25	鄔哲源 Jer-Yuarn Wu	02-27899075
AS-IRB-BM-17055 奈米粒子結合質譜儀之疾病檢測平台創新研發 Development of Disease Diagnosis by Nanoprobe-Based Affinity Mass Spectrometry	2018/01/23-2026/12/31	2018/01/23 2019/04/02 2021/11/12 2022/05/23 2023/07/24	陳玉如 Yu-Ju Chen	02-27898660
AS-IRB-BM-17056 台灣癌症登月計畫: 1. 發展新世代台灣癌症之精準醫療路徑圖(綱要計畫一、台灣癌症登月計畫); 2.重大疾病新穎治療開發－分項計畫五、多體學智慧醫療 Taiwan Cancer Moonshot Project: 1. Next-generation Pathway of Taiwan Cancer Precision Medicine (Subjective Aim 1- Taiwan Cancer Moonshot Project); 2. Development of Novel Treatments for Major Diseases (Subproject 5 – Multiomic Big Data-based Intelligent Navigation System for Precision Oncology)	2018/01/23-2035/12/31	2018/01/23 2020/09/21 2021/04/08 2021/12/27 2023/05/03 *2024/01/09	陳玉如 Yu-Ju Chen	02-27898660
AS-IRB-BM-17058 全基因體探究與自閉症相關的DNA 重組、non-co-linear RNA、環狀RNA、A-to-I RNA 編輯、與單一等位基因表現缺失事件 Global Analysis of DNA Rearrangement, non-co-linear RNA, circular RNA, A-to-I editing, and loss of monoallelic expression in Autism Spectrum Disorder	2018/02/21-2027/12/31	2018/02/21 2018/09/07 2022/11/16 *2022/12/09	莊樹諄 Trees-Juen Chuang	02-27871244
AS-IRB-BM-17061 IFIT1及IFIT3經活化Hsp90/ EGFR調控口腔癌細胞對藥物的抗性及敏感性 IFIT1 and IFIT3 modulate the drug resistance and sensitivity in oral squamous carcinoma cells via activation of Hsp90/EGFR	2018/08/01-2021/07/31	2018/05/14	李德章 Te-Chang Lee	02-26523055
AS-IRB-BM-17065 醛縮酶A非酵素功能引起肺癌細胞幹細胞化及化療抗藥性之分子機轉探討 Molecular mechanism of Aldolase A non-enzymatic function induced lung cancer cell stemness & chemotherapy resistance	2018/08/01-2021/07/31	2018/03/06	蕭宏昇 Michael Hsiao	02-27898752

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計畫名稱	執行期限	審核/修正通過日期	申請人	聯絡電話及郵件
AS-IRB-BM-17001 以強心苷類移除未分化的人類胚胎幹細胞 Elimination of undifferentiated human embryonic stem cells by cardiac glycosides	2017/02/13-2018/02/05	2017/02/13 *2017/03/31	呂仁 Jean Lu	02-27899580 #601
AS-IRB-BM-17002 闡明在肌萎縮性脊髓側索硬化症中核醣核酸及蛋白質錯置的病理機制以發展治療及早期診斷策略 Elucidating Pathogenic Mechanism of RNA/Protein Mislocalization for Developing Potential Therapeutic and Early Diagnostic Strategies in ALS	2017/04/10-2020/04/09	2017/04/10	黃人則 Jen-Tse Huang	02-27898652
AS-IRB-BM-17004 臺灣成年死亡率之社經梯度 Socioeconomic Gradient in Adult Mortality in Taiwan	2017/02/07-2020/05/28	2017/02/07 2017/02/20 2017/03/10	邱紀尊 Chi-Tsun Chiu	02-37897224
AS-IRB-BM-17007 藥物不良反應之藥物基因體學研究 A pharmacogenomic study of adverse drug reactions	2017/01/16-2021/07/31	2017/04/06 2017/12/13 2019/03/21	鄔哲源 Jer-Yuarn Wu	02-27899075
AS-IRB-BM-17009 造血幹細胞移植抗癌能力與青春 Hematopoietic Stem Cell-Based Transfer of Tumor Resistance and Juvenescence	2017/05/17-2020/04/30	2017/05/17 *2018/05/28	沈哲鯤 Che-Kun James Shen	02-27824188
AS-IRB-BM-17012 台灣心臟組織晶片計畫 Taiwan Heart Tissue Chip Project	2017/06/07-2023/04/30	2017/06/07 2017/08/04 2020/03/10 2022/03/15 2022/05/23 *2023/05/18	謝清河 Patrick Ching-Ho Hsieh	02-26523092
AS-IRB-BM-17013 探討環形非編碼核糖核酸於維持與重建多能性之機制 Investigating the roles of circular non-coding RNA in maintaining and regaining pluripotency	2017/08/01-2019/09/02	2017/03/20	余俊穎 Chun-Ying Yu 郭紘志 Hung-Chih Kuo	02-27899580 #201
AS-IRB-BM-17014 雙語與閱讀：高齡化研究 Bilingualism, Reading, and the Adaptive Aging Brain	2017/08/01-2020/07/31	2017/05/15 *2018/05/02	曾志朗 Ovid J.L. Tzeng	02-26525033
AS-IRB-BM-17016 全球衛生安全追求防疫一體之傳染病防治研究	2017/05/15-2020/12/31	2017/05/15	林國儀 Kuo-I Lin	02-27871253
AS-IRB-BM-17017 以單細胞技術建構小鼠胚胎運動神經元的四維時空命運圖譜 Using single cell technique to decode motor neuron cellular identity with 4D resolution in the mouse embryo	2017/08/01-2022/07/31	2017/04/25 *2018/01/11	陳俊安 Jun-An Chen	02-27880460
AS-IRB-BM-17019 Podocalyxin 透過膽固醇路徑調控人類胚胎幹細胞自我更新能力 Podocalyxin regulates human embryonic stem cell self-renewal through cholesterol biosynthesis	2017/05/01-2024/12/31	2017/03/23 2018/04/09 2019/04/24 *2022/04/07	呂仁 Jean Lu	02-27899580 #601
AS-IRB-BM-17020 以心房顫動疾病誘導性多潛能幹細胞分化之心肌細胞做為疾病機轉研究與藥物開發平台 A human model of atrial fibrillation by iPS-differentiated cardiomyocytes for mechanistic study and therapeutic drug innovation	2017/04/20-2018/12/31	2017/04/20	陳建璋 Chien-Chang Chen	02-26523944
AS-IRB-BM-17021 以人類誘導多能幹細胞探討非編碼RNA在脊髓肌肉萎縮症之致病機轉與治療潛能 Uncover the Role of Non-coding RNA and its Therapeutic Potential in Spinal Muscular Atrophy via Using Human Induced Pluripotent Stem Cells	2017/07/12-2021/12/31	2017/07/12 *2019/01/08	陳俊安 Jun-An Chen	02-27880460
AS-IRB-BM-17022 探討半乳糖凝集素-7 在人類肺癌演進的角色 Identification of the role of galectin-7 in lung cancer progression	2017/04/10-2020/12/31	2017/04/10	劉扶東 Fu-Tong Liu	02-26523945
AS-IRB-BM-17023 腦血管疾病之基因發現 Genetic Discovery for Cerebrovascular Disease	2017/05/11-2020/02/29	2017/05/11	鄔哲源 Jer-Yuarn Wu	02-27899075
AS-IRB-BM-17025 族群人種對藥物基因體與藥物表觀基因體之影響 The influence of population ancestry on pharmacogenomics and pharmacoepigenomics	2017/08/01-2021/07/31	2017/06/07 *2020/08/10	楊欣洲 Hsin-Chou Yang	02-27835611 #113
AS-IRB-BM-17026 上皮黏附因子及其胞外結構與單一山中申彌因子能誘導人類體細胞形成誘導型多能幹細胞 EpCAM/EpEX with single Yamanaka factor generate induced pluripotent stem cell from human somatic cells	2017/08/01-2019/07/31	2017/05/18	管奕奕 I-I Kuan 吳漢忠 Han-Chung Wu	02-27899558
AS-IRB-BM-17028 急性心肌梗塞病人血液中microRNA變化的研究 A study of circulating microRNAs in acute myocardial infarction	2017/07/12-2019/06/30	2017/07/12	謝清河 Patrick Ching-Ho Hsieh	02-26523006
AS-IRB-BM-17029 利用幹細胞及類器官技術剖析發炎性腸道疾病及消化道癌症的病理機轉並發展治療策略 Stem cell-based approaches and organotypic culture system for dissecting pathogenic mechanisms and establishing therapeutic strategies for inflammatory bowel diseases and gastrointestinal cancer	2017/08/01-2020/07/31	2017/07/12 *2019/06/18	張久瑗 Jeou-Yuan Chen	02-27899046
AS-IRB-BM-17031 探討蛋白X 對於胚胎幹細胞的生理影響 The role of Protein X in human embryonic stem cells	2017/06/22-2018/06/08	2017/06/22	陳柏仰 Pao-Yang Chen	02-27871140
AS-IRB-BM-17035 聲紋鑑識量能提升計畫委託研究採購案	2017/08/30-2021/12/31	2017/08/30 *2018/05/02	曹昱 Yu Tsao	02-27872390
AS-IRB-BM-17038 利用人類誘導式全能性幹細胞所分化之神經細胞及三維類器官體闡述非轉譯性核糖核酸於肌萎縮性脊髓側索硬化症的功能 Elucidating the Functional Role of Long Non-coding RNAs in ALS with 2D and 3D Neuronal Derivatives of Human Induced Pluripotent Stem Cells	2018/01/01-2020/12/31	2017/10/24	郭紘志 Hung-Chih Kuo	02-27899580 #201
AS-IRB-BM-17044 長期環境暴露與健康行為對於疾病發生的影響 The effect of long-term environmental exposure and health behaviors on the disease onset	2017/12/20-2022/12/31	2017/12/20 *2021/09/22	詹大千 Ta-Chien Chan	02-27857108 #312
AS-IRB-BM-17045 CTTNBP2在神經可塑性及認知功能之角色 The role of CTTNBP2 in neuronal plasticity and cognition	2017/11/06-2019/07/16	2017/10/11	薛一蘋 Yi-Ping Hsueh	02-27899311
AS-IRB-BM-17046 識別鋰鹽治療反應的遺傳位點並利用人類細胞模型探究其功能特性 Identify genetic loci for lithium treatment response and explore functional properties using human derived cellular models	2017/10/26-2021/10/01	2017/10/26	呂仁 Jean Lu	02-27899580 #601
AS-IRB-BM-17047 信號胜肽酶促進癌細胞生長之角色 The tumorigenic role of signal peptide peptidase	2017/10/24-2017/12/31	2017/10/24	趙麗洋 Lee-Young Chau	02-26523931
AS-IRB-BM-17048 建立血液循環腫瘤細胞收集及細胞培養平台以進行同步個人化精準醫學診斷與治療 Establishing a circulating tumor cell collection and culture platform for the personalized theranostics	2017/12/20-2021/09/01	2017/12/20 2020/07/30 2021/10/21	張瑛芝 Ying-Chih Chang	02-27871277
AS-IRB-BM-17050 利用資料庫資訊建立臺灣族群參考資料 To establish the Taiwanese reference by using database information	2018/04/10-2021/12/31	2018/04/10 2022/01/17 結案	沈志陽 Chen-Yang Shen	02-27899036
AS-IRB-BM-17051 利用乳癌患者血液中之循環腫瘤細胞來發展早期乳癌偵測及術後診斷之臨床應用 Detection of circulating tumor cells in peripheral blood of breast cancer patients to develop the clinical application for early breast cancer detection	2018/01/23-2020/12/31 追蹤至 2030/12/31	2018/01/23	張瑛芝 Ying-Chih Chang	02-27871277
AS-IRB-BM-17054 B型肝炎疫苗的經濟效益 Economic benefits of hepatitis B vaccination	2018/01/01-2021/12/31	2017/11/13	簡錦漢 Kamhon Kan	02-27822791 #600
AS-IRB-BM-17057 運用穿戴式裝置與大數據分析建置戶外高氣溫作業勞工熱暴險資料庫架構 Using the Wearable Device and the Big Data to Analyze the Construction of the Outdoor High Temperature Labor Risk Database	2018/02/13-2018/12/31	2018/02/13	龍世俊 Shih-Chun Candice Lung	02-26539885 #277
AS-IRB-BM-17059 經探討腸道菌與宿主腸道的功能性互動以鑑定出利用於發炎性腸道疾病的新穎生物標記及治療策略 Identification of novel biomarkers and therapeutic strategies for inflammatory bowel diseases through analysis of functional interaction between gut microbio	2018/01/23-2022/12/31	2018/01/23	嚴仲陽 Jeffrey Jong-Young Yen	02-26523077
AS-IRB-BM-17060 鑑定亨丁頓氏症病人腦組織中蛋白狀態 Identify protein status and level in the brain tissues of Huntington's disease	2018/02/01-2020/02/01	2018/01/23	陳韻如 Yun-Ru Chen	02-27871275
AS-IRB-BM-17062 半乳糖凝集素在亨丁頓舞蹈症中扮演神經發炎和神經退化的機轉研究 Galectins as the modulators of neuroinflammation and neurodegeneration in Huntington’s disease	2018/08/01-2020/06/11	2018/01/23 *2018/07/26	陳儀莊 Yi-Juang Chern	02-27899028
AS-IRB-BM-17063 藉由測量肌肉壓力閾值來區別疲勞運動所引起的肌肉的痠和痛 Discriminating muscle pain and soreness induced by exhaustion exercise with pressure pain threshold	2018/02/05-2020/12/31	2018/02/05 2019/02/15 2020/04/30	陳志成 Chih-Cheng Chen	02-27899057
AS-IRB-BM-17064 利用小分子藥物提升間質幹細胞的功能性 Improve the functions of mesenchymal stem cells by chemical cocktails	2018/04/10-2022/12/31	2018/04/10	呂仁 Jean Lu	02-27899580 #601
AS-IRB-BM-17067 視幻覺在第一型躁鬱症與思覺失調症的共同基因 Common genes for visual hallucination in bipolar I disorder and schizophrenia	2018/08/01-2021/07/31	2018/05/02	鄭泰安 Andrew Cheng	02-27899119
AS-IRB-BM-17068 探討CD44v6促進細胞移行/細胞侵犯及腫瘤轉移的機制 To study the molecular mechanisms underlying CD44v6-elicited cell migration, cell invasion, and tumor metastasi	2018/08/01-2019/07/31	2017/12/29	張久瑗 Jeou-Yuan Chen	02-26523966
AS-IRB-BM-17069 以人體餵食試驗及世代巢式病例對照研究探討炸油產生之氧脂質和心臟血管疾病、大直腸癌風險以及和發炎相關細胞激素之關係 Human Feeding Study and Nested Case-control Studies on Associations between Oxylipins, Cytokine Profile, and Risk of Colorectal Cancer and Cardiovascular Diseases	2018/08/01-2023/12/31	2018/05/08	潘文涵 Wen-Harn Pan	02-27899121
AS-IRB-BM-17070 關於DUPAN2和唾液酸Lewis A聚醣在胚胎幹細胞和腫瘤幹細胞中與微核糖核酸間維持幹細胞幹性作用的研究 Study on the roles of micro-RNAs in maintenance of stemness in ES and CSC cells focusing on DUPAN2 and sialyl Lewis A glycans	2018/08/01-2019/07/04	2018/01/05	神奈木玲兒 Kannagi, Reiji	02-26523976
AS-IRB-BM-17071 研發標靶藥物傳輸系統於癌症治療及造影 Development of Targeting Drug Delivery Systems for Cancer Therapy and Imaging	2018/07/01-2020/08/14	2018/01/11	吳漢忠 Han-Chung Wu	02-27899528

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自99年10月1日起，本院醫學研究倫理委員會審核通過之計畫於執行期間，進行無實質造成受試者風險及利益改變之微小修正，經本院醫學研究倫理委員會審核同意可不需另行通知受試者之資訊公告如下，歡迎查閱。

計畫名稱	執行期限	審核/修正通過日期	申請人	聯絡電話及郵件
AS-IRB-BM-17003 探索序列資料的維度降低與連鎖分析在稀少性變異資料的應用議題 Exploring the issues of dimension reduction and the usage of rare variants in linkage analysis with sequence data	2017/03/08-2022/12/31	2017/03/08 *2020/03/30 (展延)	范盛娟 Cathy Shen-Jang Fann	02-27899144
AS-IRB-BM-17006 結合dbGap 和 Taiwan Biobank 資料庫以偵測族群異質性分析及基因交互作用 Investigating gene-gene interaction and population heterogeneity by combining dbGap and Tiawan Biobank databases	2017/03/08-2025/12/31	2017/03/08 2017/10/12 2018/01/22 2018/05/08 2019/07/22 2019/10/03 2020/03/18 2020/04/28 2022/07/08 (展延)	范盛娟 Cathy Shen-Jang Fann	02-27899144
AS-IRB-BM-17007 藥物不良反應之藥物基因體學研究 A pharmacogenomic study of adverse drug reactions	2017/01/16-2021/07/31	2017/04/06 2017/12/13 2019/03/21 (展延)	鄔哲源 Jer-Yuarn Wu	02-27899075
AS-IRB-BM-17012 台灣心臟組織晶片計畫 Taiwan Heart Tissue Chip Project	2017/06/07-2022/04/30	2017/06/07 2017/08/04 2020/03/10 (展延)	謝清河 Patrick Ching-Ho Hsieh	02-26523092
AS-IRB-BM-17036 尋找與大腸直腸癌易感性與癌症演進相關的基因與致癌性miRNA研究合作計劃（3） Identification of Genes and Oncogenic miRNAs Involved in Colorectal Cancer Susceptibility and Progression (3)	2017/08/09-2025/12/31	2017/08/09 2018/07/26 (展延) 2022/11/21 (展延)	李玲慧 Ling‐Hui Li	02-27899078
AS-IRB-BM-17040 居住安排與健康餘命之關係 The association between living arrangement and health expectancy	2017/08/30-2020/08/31	2017/08/30 *2018/07/30 (展延)	邱紀尊 Chi-Tsun Chiu	02-37897224

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計畫名稱	執行期限	撤案日期	申請人	聯絡電話及郵件
AS-IRB-BM-17011 探討USP11 在胚胎和成人神經發育上的功能、機制及疾病治療之應用 The functions and molecular mechanisms of USP11 in regulating embryonic and adult neurogenesis and its potential therapeutic application	2017/08/01-2020/07/31	2017/03/07 *2018/07/03 撤案	吳佩容 Pei-Rung Wu 陳瑞華 Ruey-Hwa Chen	02-27855696 #6021 #6020
AS-IRB-BM-17027 建立以膜蛋白之醣基為標靶的類風溼性關節炎精準新療法 Targeting cell surface glycans of synoviocytes for therapeutic interventions in rheumatoid arthritis	2017/08/01-2021/07/31	2017/07/12 *2018/07/05 撤案	孟子青 Tzu-Ching Meng	02-27855696 #6010
AS-IRB-BM-17066 家庭語文環境、失匹配反應與語言發展之相關性: 六至三十六個月齡追蹤研究 The Relationships among Home Literacy Environment, Mismatch Response and Language Outcome: A Longitudinal Study from 6 to 36 Months of Age	2018/02/27-2019/06/30 追蹤至 2021/12/31	2018/02/27 *2019/03/04 撤案	李佳穎 Chia-Ying Lee	02-26525031